The greatest rebellion in colonial America was the Revolution that secured the independence of the united States of America from Great Britain. The lowercase "united" in the preceding sentence is deliberate as this was how it was rendered in the Declaration of Independence which also stated:
That these United Colonies are, and of Right ought to be Free and Independent States; that they are Absolved from all Allegiance to the British Crown, and that all political connection between them and the State of Great Britain, is and ought to be totally dissolved; and that as Free and Independent States, they have full Power to levy War, conclude Peace, contract Alliances, establish Commerce, and to do all other Acts and Things which Independent States may of right do.